Fri Dec 02 2022

62 articles - From Friday Nov 25 2022 to Friday Dec 02 2022

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Endoscopy

Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.

MR11: ESGE recommends DAE-endoscopic retrograde cholangiopancreatography (DAE-ERCP) as a first-line endoscopic approach to treat pancreaticobiliary diseases in patients with surgically altered anatomy (except for Billroth II patients). Strong recommendation, moderate quality evidence.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther

Systematic review: the role of frailty in advanced chronic liver disease.

Various frailty tools can reproducibly evaluate mortality in patients with cirrhosis who are ineligible for transplant. However, further prospective head-to-head comparative studies are needed. In addition to determining model utility, studies should focus on important relative considerations which may limit widespread implementation including, ease of use and limited resources, given the global disparity of liver care provision. These tools may positively identify specific patient cohorts at risk of impending deterioration, thereby stratifying those patients likely to benefit from early integration with palliative care.

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Clin Gastroenterol Hepatol

Mortality and liver-related events in lean versus non-lean non-alcoholic fatty liver disease: a systematic review and meta-analysis.

This study highlights a higher risk of liver-related mortality in patients with lean NAFLD than those with non-lean NAFLD. This finding indicates that further understanding of the pathophysiology, risk factors of adverse outcomes, and genetic and ethnic variabilities of lean NAFLD phenotype is warranted for individualized treatment strategies in lean NAFLD patients.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Hepatitis B virus haplotype number at baseline is a predictive marker of functional cure during antiviral therapy for patients with genotypes A and D HBeAg-positive chronic hepatitis B.

Baseline HN =2 predicts which patients with HBV genotypes A or D will more likely progress to functional cure on current direct-acting antiviral therapy, with greater accuracy than current biomarkers including baseline HBsAg and HBeAg titre.

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Am J Gastroenterol

Efficacy and safety of a novel hemostatic peptide solution during endoscopic submucosal dissection: a multicenter randomized controlled trial.

TDM-621 is a useful, easily operable hemostatic peptide for treatment of blood oozing during gastric and rectal ESDs, with no serious safety concerns.

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Gravity and the Gut: A Hypothesis of Irritable Bowel Syndrome.

This article concludes by considering the diagnostic and therapeutic implications of this new hypothesis and proposes experiments to support or reject this line of inquiry. It is hoped that the ideas in this thought experiment may also help encourage new or different ways of thinking about this common disorder.

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Immunotherapy for Cancer: Common Gastrointestinal, Liver, and Pancreatic Side Effects and Their Management.

Here, we review the commonly used US FDA-approved ICI and briefly outline their mechanism of action. We also describe the resulting collateral effects on the gastrointestinal tract, liver, and pancreas and discuss their management and prognosis.

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Immunotherapy for Cancer: Common Gastrointestinal, Liver, and Pancreatic Side Effects and Their Management.

Here, we review the commonly used US FDA-approved ICI and briefly outline their mechanism of action. We also describe the resulting collateral effects on the gastrointestinal tract, liver, and pancreas and discuss their management and prognosis.

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Meditation and Yoga for Irritable Bowel Syndrome: A Randomized Clinical Trial.

Virtually delivered yoga is safe and feasible, and effective in reducing IBS symptoms. Based on the primary end point, the intervention was not superior to an advice-only control group.

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Modified Cap-Assisted Endoscopic Mucosal Resection Versus Endoscopic Submucosal Dissection for the Treatment of Rectal Neuroendocrine Tumors =10 mm: A Randomized Noninferiority Trial.

ClinicalTrials. gov Identifier: NCT03982264.

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Periprocedural Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant Undergoing a Digestive Endoscopy.

After a contemporary standardized periprocedural management strategy, patients with AF undergoing DOAC therapy interruption for elective digestive endoscopy experienced low rates of arterial thromboembolism and major bleeding.

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Principles for Assessing Quality of Life in Patients With Crohn's Disease.

Patient-Reported Impact of Symptoms in CD provides an innovative and patient-centered framework for assessing quality of life in patients with CD, soliciting qualitative data from patient interviews, and using this to guide a cross-sectional study. Their findings should inform how clinicians guide conversations with their patients regarding quality of life.

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Clin Gastroenterol Hepatol

Clinical relevance of random biopsies from the esophagogastric junction after complete eradication of Barrett's esophagus is low.

Since EGJ-IM was not associated with a higher risk for recurrent disease, we recommend to consider abandoning random EGJ sampling after successful EET, under condition that care is provided in expert centers, and the esophagus including the EGJ is carefully inspected (Netherlands Trial Register, NL7309).

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Healthcare Costs for Medicare Patients with Hepatocellular Carcinoma in the United States.

Patients with HCC suffer from cancer-related financial burden, highlighting a need for policy interventions and financial support systems.

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Gastroenterology

PTEN deficiency facilitates exosome secretion and metastasis in cholangiocarcinoma by impairing TFEB-mediated lysosome biogenesis.

In CCA, PTEN deficiency impairs lysosome biogenesis to facilitate exosome secretion and cancer metastasis in a TFEB phosphorylation-dependent manner.

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Gut

EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial.

For treating large WON, LAMS are not superior to DPT. The techniques are associated with comparable needs for necrosectomy and hospital stay, and no gross difference in adverse events.

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Isoformic PD-1-mediated immunosuppression underlies resistance to PD-1 blockade in hepatocellular carcinoma patients.

Our findings not only revealed a mechanism underlying resistance to PD-1 ICB but also identified anti-42PD-1 antibody for HCC immunotherapy.

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Transcriptomic and immunophenotypic profiling reveals molecular and immunological hallmarks of colorectal cancer tumourigenesis.

Spatial profiling revealed the molecular and immunological landscape of CRC tumourigenesis at early disease stage. We identified biomarkers with strong association with disease progression as well as targetable immune processes that are exploitable in a clinical setting.

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J Hepatol

Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis.

Patients with cirrhosis can be stratified into HCC risk classes by variants affecting lipid turnover and Wnt-ß-catenin pathway. The incorporation of this genetic information modestly improves the performance of clinical scores. Impact and implications The identification of patients at higher probability of developing liver cancer is pivotal to improve the performance of surveillance. Risk assessment can be achieved by combining several clinical and biological parameters used in routine practice. The addition of patients' genetic characteristics can modestly improve this prediction and will ultimately pave the way for precision medicine in patients eligible for HCC surveillance, allowing physicians to trigger personalized screening strategies.

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Low alcohol consumption influences outcomes in individuals with alcohol-related compensated cirrhosis in a French multicenter cohort.

This prospective study in patients with compensated alcohol-related cirrhosis identifies factors of alcohol recurrence during the follow-up and shows that moderate alcohol consumption during follow-up negatively impacts outcomes. Patients with alcohol-related cirrhosis should be advised to stop alcohol completely. Impact and implications In patients with alcohol-related cirrhosis, data are lacking about the impact of the amount of alcohol consumed on both survival and liver events. The present study based on the CIRRAL cohort demonstrates that alcohol recurrence occurs in more than 30% of patients with compensated cirrhosis and even a moderate recurrence strongly influences outcome. Patients with compensated alcohol-related cirrhosis should be advised to completely discontinue alcohol intake, even small amounts because, from the present study, no alcohol consumption can be regarded as safe when cirrhosis has developed.

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J Neurogastroenterol Motil

Regional Differences in Intestinal Contractile Responses to Radial Stretch in the Human Lower Gastrointestinal Tract.

Radial stretch in the human colon (in vitro) evokes excitatory activity at both proximal and distal sites of the ascending colon and at the proximal site of the sigmoid colon, whereas it elicits inhibitory activity at the distal site of the sigmoid colon.

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Neurogastroenterol Motil

Benefit of extending the protocol for high resolution manometry according to the version 4.0 of the Chicago criteria. A multicenter study.

Prolongation of the time spent to complete the CCv4.0 protocol leads to a change in the diagnosis of 12% of patients. Clinically relevant changes are mainly related to the evaluation of EGJOO.

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Treatment outcomes in patients with globus: A randomized control trial of psychoeducation, neuromodulators, and proton pump inhibitors.

Both CBT and NMD provided equally effective treatment and better than PPI in patients with globus determined by the reduction in GETS. The improvement in RSI, HADS, and QoL of the three groups was not different. Given less of adverse effect than NMD, CBT should be considered as a substantial treatment.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Blue Notes.

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The AGA Equity Project: Where We Are, and Where We Go From Here.

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Neurogastroenterol Motil

Introducing the Journal's new Editors' team.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Calendar of Courses, Symposiums and Conferences.

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Response to Haseeb et al.

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Response to Hassan et al.

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Response to Scherübl.

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Tips for the Medical Management of Diverticulitis.

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Clin Gastroenterol Hepatol

Indocyanine green fluorescence imaging-assisted laparoscopic radiofrequency ablation of hepatocellullar carcinoma.

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Ménétrier Disease: A Rare Cause of Iron Deficiency Anemia.

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Under-representation of Racial and Ethnic Minorities in High-Impact Cirrhosis Clinical Trials.

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Verrucous carcinoma within a segment of esophageal intramural pseudodiverticulosis.

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Endoscopy

A double-guidewire technique for endoscopic ultrasonography-guided pancreatic drainage after pancreaticoduodenectomy.

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A hairy endoscopy.

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A successful endoscopic pancreatic stone extraction in a patient with pancreatic divisum with cholangiojejunostomy reconstruction.

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Author commentary on Agnes N. Reijm et al.

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Author commentary on Antonio Facciorusso et al.

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Author commentary on Emanuele Rondonotti et al.

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Cholangioscopy-assisted extraction of choledocholithiasis and partial sediment-like gallstones through papillary support: A pilot exploration for super minimally invasive surgery.

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Direct endoscopic necrosectomy with the newly developed 6-mm powered rotating resection catheter: When size matters.

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Endoscopic cystic duct remnant stone removal using peroral cholangioscopy.

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Endoscopic embolization of a refractory bronchobiliary fistula by endoscopic retrograde cholangiography using coils and Histoacryl.

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Endoscopic intermuscular dissection for a lower rectal gastrointestinal stromal tumor.

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Endoscopic submucosal dissection of colonic residual laterally spreading tumor with adaptive traction: use of the additional loops to improve traction focally in difficult area.

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Endoscopic ultrasound-guided gallbladder drainage followed by transcystic rendezvous ERCP for the management of distal malignant biliary obstruction.

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Novel approach for efficient removal of massive blood clots during emergency endoscopic hemostasis.

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Post-endoscopy upper gastrointestinal cancer - identifying, understanding, and improving.

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Rare case of intramural esophageal hematoma associated with betel nut consumption.

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Successful reintervention using dual-channel endoscope for perforation by partially migrated stent after endoscopic ultrasound-guided hepaticogastrostomy.

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Use of a transpapillary stent as a guidepost for endoscopic ultrasound-guided pancreatic duct drainage in the treatment of disconnected pancreatic duct syndrome.

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Usefulness of red dichromatic imagining for peroral cholangioscopy.

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J Hepatol

Liver-Related Aspects of Gene Therapy for Haemophilia: Call to Action for Collaboration between Haematologists and Hepatologists.

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Letters&Replies

Letters to the editors and authors’ replies

Clin Gastroenterol Hepatol

Comment on "Food processing and risk of Crohn's disease and ulcerative colitis: A European Prospective Cohort Study".

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Reply to Ashish Chauhan. This letter to the Editor is in response to "Similar cure rates with different routes. Can it be generalized?"; manuscript reference #: GCH-D-22-02305.

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The time is ripe for a randomized controlled trial of oral vancomycin in Primary Sclerosing Cholangitis.

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Gastroenterology

A new evaluation method for remission of ulcerative colitis.

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Letter to Editor regarding "Final Analysis of Diagnostic Endoscopic Resection Followed by Selective Chemoradiotherapy for Stage I Esophageal Cancer: JCOG0508" by Keiji Nihei et al.

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Gut

Crohn's-associated invariant T cells (CAITs) recognise small sulfonate molecules on CD1d.

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J Hepatol

Unmasking of a hepatitis c genotype 3a/1b dual infection in an individual treated with elbasvir/ grazoprevir.

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